Diversified physicochemical injuries trigger Charnoly body (CB) formation as pleomorphic electron-dense multi-lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell. Free radicals induce downregulation of mitochondrial DNA microRNA AgNOR and epigenetics to trigger CB molecular pathogenesis. CB is eliminated by energy (ATP)-driven lysosome-dependent charnolophagy as a basic molecular mechanism of intracellular detoxification to prevent acute and chronic diseases. Accumulation of CB at the junction of axon hillock and charnolosome (CS) at the synapses causes cognitive impairments; whereas nonspecific induction of CB causes GIT stress myelosuppression alopecia neurotoxicity cardiotoxicity and infertility in multidrug-resistant malignancies. Hence stem cell-specific CB charnolophagy and CS agonists/antagonists are introduced as novel charnolopharmacotherapeutics for the successful treatment of cardiovascular diseases neurodegenerative diseases infectious diseases drug addiction and cancer. Nanoparticles to improve drug delivery CS exocytosis and disease-specific spatiotemporal charnolosomics employing correlative and combinatorial bioinformatics boost mitochondrial bioenergetics through balanced diet exercise and antioxidants. The book will be of interest to medical scientists and practitioners. . Language: English